Tag Archives: Dimitrios Andreadis

Clinical Presentation and Management of Peripheral Giant Cell Granulomas in Children: 2 Cases Report

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Anna Lefkelidou1 / 2 / Elena-Lito Exarchou1 / Dimitrios Andreadis3 / Konstantinos Arapostathis1

1Aristotle University of Thessaloniki, Dental School Department of Paediatric Dentistry
2Aristotle University of Thessaloniki, Dental School Department of Oral Medicine and Oral Pathology Thessaloniki, 54124 Greece
3Aristotle University of Thessaloniki, Dental School Department of Oral Medicine and Oral Pathology Thessaloniki, Greece

Summary

Objective(s): Peripheral giant cell granuloma (PGCG) is a reactive, proliferative, exophytic lesion developing on the gingiva and alveolar ridge, originating from the periosteum or periodontal membrane. The lesion develops mostly in adults, commonly in the lower jaw, with slight female predilection although is uncommon in children.

Cases Report: Two boys, 11 and 8-years-old respectively, otherwise healthy, presented with gingival exophytic lesions in our clinic. In the first case the lesion was located in the right maxilla and appeared 4 months ago, whereas in the second case the fast growing lesion was located in the mandible and appeared 2 months ago. The lesions were red-blue enlargements, irregular and elliptical in shape respectively, soft to firm on palpation. Based on clinical examination, the initial diagnosis was assumed to be a type of reactive hyperplasia. OPG and CBCT showed no evidence of bone pathology. Blood, biochemical and hormonal investigations were within the normal values. Both lesions were surgically removed and histological examination established the diagnosis of PGCG. 4 consecutive follow ups have been done, with no evidence of recurrence.

Conclusion: This uncommon lesion in children should be included in the differential diagnosis of reactive hyperplasia. The treatment of PGCG comprises surgical resection, along with suppression of the underlying etiologic factors.

Keywords: Peripheral Giant Cell Granuloma; Dental Treatment; Giant Cell Epulis

References

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Citation Information: Balkan Journal of Dental Medicine. Volume 20, Issue 1, Pages 44–48, ISSN (Online) 2335-0245, DOI: https://doi.org/10.1515/bjdm-2016-0007, April 2016

Excessive Tongue Amyloidosis as the Diagnostic Sign of Multiple Myeloma: a Case Report

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Stylianos Dalampiras1 / 2 / Ioannis Kostopoulos3 / Florentia Stylianou4 / Ioannis Papadiochos1 / Athanasios Poulopoulos2

1School of Dentistry, Department of Oral and Maxillofacial Surgery, Aristotle University, Thessaloniki, Greece
2School of Dentistry, Department of Oral Medicine and Pathology, Aristotle University, Thessaloniki, Greece
3School of Medicine, Department of Histopathology, Aristotle University, Thessaloniki, Greece
4School of Dentistry, student, Aristotle University, Thessaloniki, Greece
5“Evangelismos” General Hospital, School of Dentistry, Athens, Greece

Summary

Background: Deposition of amyloid in oral mucosa may be related to systemic disorders, including immune-related diseases and malignancies.

Clinical Presentation: We describe a case of 76-year-old patient with excessive, painless, multi-nodular tongue enlargement, and petechiae on the vermilion border and perioral skin that appeared 2 months ago. The biopsy detected subepithelial, Congo’s Red positive amyloid depositions. Consequent laboratory investigation and bone marrow biopsy confirmed the diagnosis of multiple myeloma stage 2 (International Prognostic Index – IPI).

Conclusion: Multi-nodular excessive tongue enlargement could be of high significance as initial sign of undiagnosed, underlying systemic disease including severe malignancy like multiple myeloma.

Keywords: Oral Amyloidosis; Macroglossia; Multiple Myeloma

References

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Citation Information: Balkan Journal of Dental Medicine. Volume 19, Issue 1, Pages 50–52, ISSN (Online) 2335-0245, DOI: https://doi.org/10.1515/bjdm-2015-0034, July 2015