Skip to content
  • Basic research
  • Dental materials
  • Endodontics
  • Imaging
  • Implants
  • Infection control
  • Medically compromised and patients with special needs
  • Oral and maxillofacial surgery
  • Oral hygiene
  • Orthodontics
  • Other
  • Pediatric and preventive dentistry
  • Periodontics and oral medicine
  • Pharmacology
  • Prosthodontics
  • Restorative and aesthetic dentistry

Select Issue

  • Online First
  • 2024
    • Vol 28 – Issue 2
    • Vol 28 – Issue 1
  • 2023
    • VOL 27 – ISSUE 1
    • VOL 27 – ISSUE 2
    • VOL 27 – Issue 3
  • 2022
    • VOL 26 – ISSUE 1
    • VOL 26 – ISSUE 2
    • VOL 26 – ISSUE 3
  • 2021
    • VOL 25 – ISSUE 1
    • VOL 25 – ISSUE 2
    • VOL 25 – ISSUE 3
  • 2020
    • VOL 24 – ISSUE 1
    • VOL 24 – ISSUE 2
    • VOL 24 – ISSUE 3
  • 2019
    • VOL 23 – ISSUE 1
    • VOL 23 – ISSUE 2
    • VOL 23 – ISSUE 3
  • 2018
    • VOL 22 – ISSUE 1
    • VOL 22 – ISSUE 2
    • VOL 22 – ISSUE 3
  • 2017
    • VOL 21 – ISSUE 1
    • VOL 21 – ISSUE 2
    • VOL 21 – ISSUE 3
  • 2016
    • VOL 20 – ISSUE 1
    • VOL 20 – ISSUE 2
    • VOL 20 – ISSUE 3
  • 2015
    • VOL 19 – ISSUE 1
    • VOL 19 – ISSUE 2
    • VOL 19 – ISSUE 3
  • 2014
    • VOL 18 – ISSUE 1
    • VOL 18 – ISSUE 2
    • VOL 18 – ISSUE 3
  • Issue Archive
Skip to content
  • Balkan Stomatological Society
balkan.dentistry@hotmail.com
  • Facebook
Submit Manuscript
  • Facebook
Balkan Journal of Dental Medicine

Balkan Journal of Dental Medicine

Official Publication of the Balkan Stomatological Society

Submit Manuscript
  • Home
  • For Authors
    • Author Guidelines
    • Submit Your Manuscript
  • Articles and Issues
    • Online First
    • Issue Archive
      • 2024 YEAR
        • Vol 28 – Issue 2
        • Vol 28 – Issue 1
      • 2023 YEAR
        • VOL 27 – ISSUE 1
        • VOL 27 – ISSUE 2
        • VOL 27 – ISSUE 3
      • 2022 YEAR
        • VOL 26 – ISSUE 1
        • VOL 26 – ISSUE 2
        • VOL 26 – ISSUE 3
      • 2021 YEAR
        • VOL 25 – ISSUE 1
        • VOL 25 – ISSUE 2
        • VOL 25 – ISSUE 3
      • 2020 YEAR
        • VOL 24 – ISSUE 1
        • VOL 24 – ISSUE 2
        • VOL 24 – ISSUE 3
      • 2019 YEAR
        • VOL 23 – ISSUE 1
        • VOL 23 – ISSUE 2
        • VOL 23 – ISSUE 3
      • 2018 YEAR
        • VOL 22 – ISSUE 1
        • VOL 22 – ISSUE 2
        • VOL 22 – ISSUE 3
      • 2017 YEAR
        • VOL 21 – ISSUE 1
        • VOL 21 – ISSUE 2
        • VOL 21 – ISSUE 3
      • 2016 YEAR
        • VOL 20 – ISSUE 1
        • VOL 20 – ISSUE 2
        • VOL 20 – ISSUE 3
      • 2015 YEAR
        • VOL 19 – ISSUE 1
        • VOL 19 – ISSUE 2
        • VOL 19 – ISSUE 3
      • 2014 YEAR
        • VOL 18 – ISSUE 1
        • VOL 18 – ISSUE 2
        • VOL 18 – ISSUE 3
      • Issue Archive
  • Categories
    • Oral and maxillofacial surgery
    • Periodontics and oral medicine
    • Pediatric and preventive dentistry
    • Restorative and aesthetic dentistry
    • Prosthodontics
    • Endodontics
    • Medically compromised and patients with special needs
    • Basic research
    • Orthodontics
    • Uncategorized
  • About Us
    • Aims and Scope
    • Editorial Board
    • Publication Policy
  • Contact Us

Lesion sterilization and tissue repair (LSTR) method in irreversible dental pulp changes of primary teeth

vuksavicMarch 20, 2023March 20, 2023

Download Article

Zukanović Amila, Bajrić Elmedin, Marković Nina, Duratbegović Damir, Katana Elma, Čengić Emina, Serhatlić Senka, Pejak Hasan

University of Sarajevo, Faculty of Dentistry with Clinics, Federation of B&H

Abstract

Background/Aim: Deep carious lesions on primary teeth usually have been causing infectious dental pulp changes. If indicated, traditional endodontic root canal treatment for these kinds of pulpal infections in primary teeth usually should involve the performing of pulpectomy methods, but often with questionable prognosis. The lesion sterilization and tissue repair (LSTR) approach is one of the good endodontic therapeutic alternatives for affected primary teeth with a poor prognosis, which could otherwise be condemned to premature extraction. Aim was to evaluate the medium-term clinical success in everyday practice of the LSTR method applied in affected primary teeth with irreversible pulpal tissue infections by observation of reduction/absence of their clinical symptoms. Material and methods: The study sample included child patients who had one or more of their affected primary molars with irreversible pulpal tissue changes of poor prognosis treated with the LSTR method. For each patient whose primary molar tooth was endodontically treated with the LSTR method a clinical evaluation of treated tooth was performed at intervals of 1 and 12 months afterwards. Results: Study sample was consisted of 40 child patients aged 4 to 9 years, with 45 primary molars included in total. It was obvious that the symptoms related to affected sample teeth have already been decreased almost immediately after initial action of triple antibiotic paste. Final outcome after 12-months follow-up period was success of applied LSTR method in 43 (95.6%) affected sample teeth in a way that initial clinical symptoms completely decreased and disappeared. Conclusions: LSTR method has been shown as successful pulpotomy technique for noninstrumental endodontic approach in non-vital pulp treatment of primary molar teeth in a 12-months follow-up period.

Keywords: paediatric dentistry; endodontics; primary teeth; LSTR

Reference

Cameron AC, Widmer RP (eds.). Handbook of Pediatric Dentistry. 4th Edition. Mosby; 2013

Nowak AC, Christensen J, Mabry T, Townsed J, Wells M (eds.) Pediatric Dentistry Infancy Through Adolescence. 6th edition. Saunders; 2018

Dean JA, Jones JE, Walker Vinson LA (eds.). McDonald and Avery’s Dentistry for the Child and Adolescent. 10th edition. Elsevier; 2016

Welbury R, Duggal MS, Hosey MT (eds.). Paediatric dentistry. 5th edition. Oxford University Press; 2018

Fuks AB, Benjamin P. Pediatric Endodontics-Current Concepts in Pulp Therapy for Primary and Young Permanent Teeth. Springer; 2016

Ritwik P. A review of pulp therapy for primary and immature permanent teeth. J Calif Dent Assoc, 2013;41:585-595

Hamed MH, Gul M, Ghafoor R, Badar SB. Management of immature necrotic permanent teeth with regenerative endodontic procedures -a review of literature. J Pak Med Assoc, 2019;69:1514-1520

Nicoloso GF, Potter IG, de Oliveira Rocha R, Montagner F, Casagrande L. A comparative evaluation of endodontic treatments for immature necrotic permanent teeth based on clinical and radiographic outcomes: a systematic review and meta-analysis. Int J Paediatr Dent, 2017;27:217-227

Sato T, Hoshino E, Uematsu H, Kota K, Iwaku M, Noda T. Bactericidal Efficacy of a Mixture of Ciprofloxacin, Metronidazole, Minocycline and Rifampicin against Bacteria of Carious and Endodontic Lesions of Human Deciduous Teeth In Vitro. Microb Ecol Health Dis, 1992;5:171-717

Hoshino E. Sterilization of carious lesions by drugs. JJADS, 1990;9:32-37

Sato T, Hoshino E, Uematsu H, Noda T. In vitro antimicrobial susceptibility to combinations of drugs of bacteria from carious and endodontic lesions of human deciduous teeth. Oral Microbiol Immunol, 1993;8:172-176

Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, et al. In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J, 1996;29:125-130

Sato I, Kurihara-Ando N, Kota K, Iwaku M, Hoshino E. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole and minocycline in situ. Int Endod J, 1996;29:118-124

Takushige T, Cruz EV, Asgor Moral A, Hoshino E. Endodontic treatment of primery teeth using a combination of antibacterial drugs. Int Endod J, 2004;37:132-138

Anila B, Murali H, Cheranjeevi J, Kapil RS. Lesion Sterilization and Tissue Repair (LSTR): A Review. J Sci Dent, 2014;4:49-55

Prabhakar AR, Sridevi E, Raju OS, Satish V. Endodontic treatment of primary teeth using combination of antibacterial drugs: An in vivo study. J Indian Soc Pedod Prevent Dent, 2008;26:S5-10

Nakornchai S, Banditsing P, Visetratana N. Clinical evaluation of 3Mix and Vitapex as treatment options for pulpally involved primary molars. Int J Paediatr Dent, 2010;20:214-221

Agarwal M, Das UM, Vishwanath D. A Comparative Evaluation of Noninstrumentation Endodontic Techniques with Conventional ZOE Pulpectomy in Deciduous Molars: An in vivo Study. World J Dent, 2011;2:187-192

Pinky C, Shashibhushan KK, Subbareddy VV. Endodontic treatment of necrosed primary teeth using two different combinations of antibacterial drugs: An in vivo study. J Indian Soc Pedod Prev Dent, 2011;29:121-127

Trairatvorakul C, Detsomboonrat P. Success rates of a mixture of ciprofloxacin, metronidazole, and minocycline antibiotics used in the non-instrumentation endodontic treatment of mandibular primary molars with carious pulpal involvement. Int J Paediatr Dent, 2012;22:217-227

Bansal R, Jain A. Overview on the Current Antibiotic Containing Agents Used in Endodontics. N Am J Med Sci, 2014;6:351-358

Doneria D, Thakur S, Singhal P, Chauhan D. Comparative evaluation of clinical and radiological success of zinc oxide-ozonated oil, modified 3mix-mp antibiotic paste, and vitapex as treatment options in primary molars requiring pulpectomy: An in vivo study. J Indian Soc Pedod Prev Dent, 2017;35:346-352

Lokade A, Thakur S, Singhal P, Chauhan D, Jayam C. Comparative evaluation of clinical and radiographic success of three different lesion sterilization and tissue repair techniques as treatment options in primary molars requiring pulpectomy: An in vivo study. J Indian Soc Pedod Prev Dent, 2019;37:185-191

Coll JA, Dhar V, Vargas K, Chen CY, Crystal YO, AlShamali S, et al. Use of Non-Vital Pulp Therapies in Primary Teeth. Pediatr Dent, 2020;42:337-349

Coll JA, Vargas K, Marghalani AA, Chen CY, AlShamali S, Dhar V, et al. A Systematic Review and Meta-Analysis of Nonvital Pulp Therapy for Primary Teeth. Pediatr Dent, 2020;42:256-272

Duarte ML, Pires PM, Masterson Ferreira DM, Vaz Braga Pintor A, de Almeida Neves A, Cople Maia LC, et al. Is there evidence for the use of lesion sterilization and tissue repair therapy in the endodontic treatment of primary teeth? A systematic review and meta-analyses. Clin Oral Invest, 2020;24:2959-2972

American Academy of Pediatric Dentistry. Pulp therapy for primary and immature permanent teeth. The Reference Manual of Pediatric Dentistry. Chicago, Ill.: American Academy of Pediatric Dentistry, 2021:399-407

World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA, 2013;310:2191-2194

Sijini OT, Sabbagh HJ, Baghlaf KK, Bagher AM, El-Housseiny AA, Alamoudi NM, Bagher SM. Clinical and radiographic evaluation of triple antibiotic paste pulp therapy compared to Vitapex pulpectomy in non-vital primary molars. Clin Exp Dent Res, 2021;7:819-828

Zacharczuk GA, Toscano MA, López GE, Ortolani AM. Evaluation of 3Mix-MP and pulpectomies in non-vital primary molars. Acta Odontol Latinoam, 2019;32:22-28

Raslan N, Mansour O, Assfoura L. Evaluation of antibiotic mix in Non-instrumentation Endodontic Treatment of necrotic primary molars. Eur J Paediatr Dent, 2017;18:285-290

Chouchene F, Masmoudi F, Baaziz A, Maatouk F, Ghedira H. Antibiotic Mixtures in Noninstrumental Endodontic Treatment of Primary Teeth with Necrotic Pulps: A Systematic Review. Int J Dent, 2021;2021:5518599

Garrocho-Rangel A, Jalomo-Ávila C, Rosales-Berber MÁ, Pozos-Guillén A. Lesion Sterilization Tissue Repair (LSTR) Approach Of Non-Vital Primary Molars With A Chloramphenicol-Tetracycline-ZOE Antibiotic Paste: A Scoping Review. J Clin Pediatr Dent, 2021;45:369-375

Agarwal SR, Bendgude VD, Kakodkar P. Evaluation of Success Rate of Lesion Sterilization and Tissue Repair Compared to Vitapex in Pulpally Involved Primary Teeth: A Systematic Review. J Conserv Dent, 2019;22:510-515

Moura J, Lima M, Nogueira N, Castro M, Lima C, Moura M, Moura L. LSTR Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for the Treatment of Primary Molars with Pulp Necrosis: A Randomized Controlled Trial. Pediatr Dent, 2021;43:435-442

Nalawade TM, Parikh D and Mallikarjuna RM. Lesion Sterilization and Tissue Repair (LSTR) Technique and its Clinical Application in Primary and Permanent Teeth: A Review. Ann Essence Dent, 2019;11:1-6

Satenahalli SB, Vardhana BS, Surana P, Gopal R, Ranjan AP, et al. Lesion Sterilization and Tissue Repair (LSTR): A Review. Eur J Mol Clin Med, 2020;7:7909-7914

Shankar K, Ramkumar H, Dhakshinamoorthy S, Paulindraraj S, Jayakaran TG, Bommareddy CS. Comparison of Modified Triple Antibiotic Paste in Two Concentrations for Lesion Sterilization and Tissue Repair in Primary Molars: An In Vivo Interventional Randomized Clinical Trial. Int J Clin Pediatr Dent, 2021;14:388-392

Arslan H, Ahmed HMA, Şahin Y, Doğanay Yıldız E, Gündoğdu EC, Güven Y, et al. Regenerative Endodontic Procedures in Necrotic Mature Teeth with Periapical Radiolucencies: A Preliminary Randomized Clinical Study. J Endod, 2019;45:863-872

Cross R, Ling C, Day NP, McGready R, Paris DH. Revisiting doxycycline in pregnancy and early childhood-time to rebuild its reputation? Expert Opin Drug Saf, 2016;15:367-382

Dilley M, Geng B. Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole. Clin Rev Allergy Immunol. 2022 Jun;62(3):463-475

Balkan Journal of Dental Medicine, 2023, vol. 27, br. 1, str. 15-20

Post navigation

Previous: Composite plastering technique (CPT) for anterior and posterior restorations
Next: Quality of life in patients surgically treated for oral carcinoma

Categories

  • Basic research
  • Dental materials
  • Endodontics
  • Imaging
  • Implants
  • Infection control
  • Medically compromised and patients with special needs
  • Oral and maxillofacial surgery
  • Oral hygiene
  • Orthodontics
  • Other
  • Pediatric and preventive dentistry
  • Periodontics and oral medicine
  • Pharmacology
  • Prosthodontics
  • Restorative and aesthetic dentistry
  • Facebook
  • Author Guidelines
  • Publication Policy
  • Editorial Board
  • Submit Manuscript
  • Contact us
All Rights Reserved | Theme: BlockWP by Candid Themes.
Go to Balkan Stomatological Society