Marinković Jelenaa, Rakašević Draganab, Nemoda Milicac, Nikolić Biljanad, Marković Tatjanad, Matijević Stevoe, Marković Dejanf
aUniversity of Belgrade, Institute of Nuclear Sciences ‘Vinča’, Belgrade-Vinča, Serbia
bUniversity of Belgrade, Faculty of Dental Medicine, Department of Oral Surgery, Serbia
cUniversity of Belgrade, Faculty of Biology, Serbia
dInstitute for Medicinal Plant Research ‘Dr. Josif Pančić ‘, Belgrade, Serbia
eMilitary Medical Academy, Clinic for Stomatology, Belgrade, Serbia
fUniversity of Belgrade, Faculty of Dental Medicine, Department of Paediatric and Preventive Dentistry, Serbia
Abstract
The possibility to utilize the antibacterial and antibiofilm potential of essential oils (EOs) in dentistry is recognized and best seen in the design of EO-based mouthwashes. The up-to-date results, obtained with the most commonly used formulation being consisted of thymol, eucalyptol, menthol, and methyl salicylate (Listerine), proved its efficacy against plaque and gingival inflammation. However, novel alcohol-free products remain to be further investigated. Commercially available mouthwash containing curcumin, clove oil, mentha oil, eucalyptol, thymol and tea tree oil, and the mouthwash based on ginger EO (a-zingiberene, b-bisabolene, b-sesquiphellandrene, curcumene), reduced plaque index and improved periodontal status of the patients. The plaque index was also reduced and overall healing was improved after the surgical removal of the third molar by mouthwash containing John wort oil. In addition, Cinnamomum zeylanicum EO-based mouthwash and mouthwash containing peppermint oil were efficient against stomatitis and xerostomia, respectively. In addition to beneficial effects achieved in the mouth, i.e. at the appropriate site of application, novel investigations pointed-out that EO-based mouthwashes could be recognized as efficient in the reduction of bacterial and viral aerosols. This has been shown for Listerine, and for several mouthwashes containing following active substances of plants’ EO origin: a-farnesene, b-farnesene, farnesol, nerolidol, a-bulnesene, eremanthin, b-sesquiphellandrene, spiroether, cinnamylacetate, cinnamaldehyde, eugenol, menthol, and carvacrol. This finding could be of special interest, in order to be included in further clinical studies related to COVID -19 pandemic.
Keywords: COVID-19; essential oil; mouthwash; periodontal disease; oral hygiene; plaque
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Balkan Journal of Dental Medicine, 2023, vol. 27, br. 1, str. 32-37