Oral Ulceration Due to Methotrexate Treatment: A Report of 3 Cases and Literature Review

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Theodoros Dervisoglou1 / 2

1DMD, Private Dentist
2Aristotle University of Thessaloniki, School of Dentistry, Dept. of Oral Medicine and Pathology, Greece


Methotrexate (MTX) is an antimetabolite which interferes with DNA synthesis. It is used for the treatment of many diseases, such as psoriasis, rheumatoid arthritis and various neoplastic diseases. It may cause, among various adverse reactions, oral ulceration and oral mucositis. 3 cases of methotrexate related oral ulcers are reported along with a brief review of the relevant literature.

Keywords: Oral Ulceration; Methotrexate; Rheumatoid Arthritis; Psoriatic Arthritis


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Citation Information: Balkan Journal of Dental Medicine. Volume 19, Issue 2, Pages 116–120, ISSN (Online) 2335-0245, DOI: https://doi.org/10.1515/bjdm-2015-0045, July 2015