1Faculty of Medicine, University of East Sarajevo, Foca, Bosnia and Herzegovina
2Faculty of Dental Medicine, University of Belgrade, Belgrade, Serbia
3University Hospital, Foca, Bosnia and Herzegovina
Background: Good glycoregulation at patients with diabetes mellitus is essential for prevention of many complications, including those in oral cavity. Results of numerous studies indicate that xerostomia and neurosensory oral disorders are present in type 2 diabetics. A review of the literature shows contradictory results about prevalence of oral mucosal lesions in diabetics. The aim of this study was to evaluate the presence of xerostomia, neurosensory disorders and mucosal lesions in oral cavity of type 2 diabetics.
Material and Methods: This study involved 90 adults, 60 with type 2 diabetes and 30 healthy subjects, aged 45-65 years. With regard to value of HbA1c level diabetics were divided into two groups: 30 subjects with satisfactory glycoregulation (HbA1c<9%) and 30 subjects with poor glycoregulation (HbA1c≥9%). All patients recruited into the study completed a questionnaire that included their demographic, medical and oral health data. Clinical examination of the oral mucosa was performed by a single examiner.
Results: In relation to the presence of xerostomia and dysgeusia between satisfactory controlled diabetics and healthy subjects a significant difference was observed (p<0.05). Compared with healthy subjects, poor controlled diabetics had significantly higher presence of xerostomia (p<0.001) and neurosensory disoders (p<0.05). A higher prevalence of oral mucosal lesions was found in poor controlled diabetics, but significant difference between groups was not observed (p>0.05). A significant positive correlation was revealed between smoking and glossodynia as well as smoking and glossopyrosis (p>0.05).
Conclusion: Glycemic control level seems to influence the susceptibility of type 2 diabetics to xerostomia and neurosensory disorders. Less clear is whether diabetes are corellated to oral mucosal lesions.
- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care, 2014; 37:S81-90.
- Alba-Loureiro TC, Munhoz CD, Martins JO, Cerchiaro GA, Scavone C, Curi R, Sannomiya P. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res, 2007; 40:1037-1044.[Crossref]
- Gurav A, Jadhav V. Periodontitis and risk of diabetes mellitus. J Diabetes, 2011; 3:21-28.[Crossref] [Web of Science]
- Moore PA, Guggenheimer J, Etzel KR, Weyant RJ, Orchard T. Type 1 diabetes mellitus, xerostomia and salivary flow rates. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001; 92:281-291.[Crossref]
- Sreebny LM, Vissink A (ed). Dry mouth, the malevolent symptom: a clinical guide. Singapore: Wiley-Blackwell, 2010.
- Shepard IM. Oral manifestation of diabetes mellitus: a study of one hundred cases. J Am Dent Assoc, 1942; 29:1188-1192.[Crossref]
- Collin HL, Niskanen L, Uusitupa M, Töyry J, Collin P, Koivisto AM et al. Oral symptoms and signs in elderly patients with type 2 diabetes mellitus. A focus on diabetic neuropathy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2000; 90:299-305.
- Stolbova K, Hahn A, Benes B, Andel M, Treslova L. Gustometry of diabetes mellitus patients and obese patients. Int Tunnitus J, 1999; 5:135-140.
- Fomina EI, Pozharitskaia MM, Davydov AL, Starosel’tseva LK, Budylina SM, Simakova TG. Changes of gustatory perception in elderly patients with type II sugar diabetes. Surgical section. Stomatologiia (Mosk), 2007; 86:30-34.
- Gondivkar SM, Indurkar A, Degwekar S, Bhowate R. Evaluation of gustatory function in patients with diabetes mellitus type 2. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2009; 108:876-880.
- Lamster IB, Lalla E, Borgnakke WS, Taylor GW. The relationship between oral health and diabetes mellitus. JADA, 2008; 139:19S-24S.
- Saini R, Al-Maweri SA, Saini D, Ismail NM, Ismail AR. Oral mucosal lesions in non oral habit diabetic patients and association of diabetes mellitus with oral precancerous lesions. Diabetes Res Clin Pract, 2010; 89:320-326.[Crossref] [Web of Science]
- Chávez EM, Borrell LN, Taylor GW, Ship JA. A longitudinal analysis of salivary flow in control subjects and older adults with type 2 diabetes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2001; 91:166-173.
- Zielinski MB, Fedele D, Forman LJ, Pomerantz SC. Oral health in the elderly with non-insulin-dependent diabetes mellitus. Spec Care Dentist, 2002; 22:94-98.
- Cho MA, Ko JY, Kim YK, Kho HS. Salivary flow rate and clinical characteristics of patients with xerostomia according to its aetiology. J Oral Rehabil, 2010; 37:185-193.[Crossref] [Web of Science]
- Kramer IR, Pindborg JJ, Bezroukov V, Infirri JS. Guide to epidemiology and diagnosis of oral mucosal diseases and conditins. World Health Organization. Community Dent Oral Epidemiol, 1980; 8:1-26.[Crossref]
- Yamamoto K, Kurihara M, Matsusue Y, Imanishi M, Tsuyuki M, Kirita T. Whole saliva flow rate and body profile in healthy young adults. Arch Oral Biol, 2009; 54:464-469.[Web of Science] [Crossref]
- Anderson LC. Hormonal regulation of salivary glands, with particular reference to experimental diabetes. In: Garrett JR, Ekström J, Anderson LC, (ed). Glandular mechanisms of salivary secretion. Frontiers of oral biology. Basel: Karger, 1998, pp 200-221.
- Narhi TO, Meurman JH, Ainamo A. Xerostomia and Hyposalivation. Drugs & Aging, 1999; 15:103-116.[Crossref]
- Navea Aguilera C, Guijarro de Armas MG, Monereo Megías S, Merino Viveros M, Torán Ranero C. The relationship between xerostomia and diabetes mellitus: a little known complication. Endocrinol Nutr, 2015; 62:45-46.[Crossref]
- Busato IMS, Ignácio SA, Brancher JA, Moysés ST, Azevedo-Alanis LR. Impact of clinical status and salivary conditions on xerostomia and oral health-related quality of life of adolescents with type 1 diabetes mellitus. Community Dent Oral Epidemiol, 2012; 40:62-69.[Crossref] [Web of Science]
- Sandberg GE, Wikblad KF. Oral health and health-related quality of life in type 2 diabetic patients and non-diabetic controls. Acta Odontol Scand, 2003; 61:141-148.
- Carda C, Mosquera-Lloreda N, Salom L, Gomez de Ferraris ME, Peydró A. Structural and functional salivary disorders in type 2 diabetic patients. Med Oral Patol Oral Cir Bucal, 2006; 11:E309-314.
- Sandberg GE, Sundberg HE, Fjellstrom CA, Wikblad KF. Type 2 diabetes and oral health. A comparison between diabetic and non-diabetic subjects. Diabetes Res Clin Pract 2000; 50:27-34.
- Mese H, Matsuo R: Salivary secretion, taste and hyposalivation. J Oral Rehabil, 2007; 34:711-723.[Crossref] [Web of Science]
- Klasser GD, Fischer DJ, Epstein JB. Burning mouth syndrome: recognition understanding and management. Oral Maxillofac Surg Clin North Am, 2008; 20:255-271.
- Perros P, Counsell C, MacFarlane TW, Frier BM. Altered taste sensation in newly-diagnosed NIDDM. Diabetes Care, 1996; 19:768-770.[Crossref]
- De Lima DC, Nakata GC, Balducci I, Almeida JD. Oral manifestations of diabetes mellitus in complete denture wearers. J Prosthet Dent, 2008; 99:60-65.[Crossref] [Web of Science]
- Bastos AS, Leite AR, Spin-Neto R, Nassar PO, Massucato EM, Orrico SR. Diabetes mellitus and oral mucosa alterations: Prevalence and risk factors. Diabetes Res Clin Pract, 2011; 92:100-105.[Crossref]
- Seyhan M, Özcan H, Sahin I, Bayram N, Karincaoglu Y. High prevalence of glucose metabolism disturbance in patients with lichen planus. Diabetes Res Clin Pract, 2007; 77:198-202.[Web of Science] [Crossref]
- Manfredi M, McCullough MJ, Vescovi P, Al-Kaarawi ZM, Porter SR. Update on diabetes mellitus and related oral diseases. Oral Dis, 2004; 10:187-200.[Crossref]
- Al-Maweri SA, Ismail NM, Ismail AR, Al-Ghashm A. Prevalence of oral mucosal lesions in patients with type 2 diabetes attending hospital Universiti Sains Malaysia. Malays J Med Sci, 2013; 20:39-46.
- Delamaire M, Maugendre D, Moreno M, Le Goff M, Allannic H, Genetet B. Impaired leucocyte functions in diabetic patients. Diabet Med, 1997; 14:29-34.[Crossref]
Citation Information: Balkan Journal of Dental Medicine. Volume 21, Issue 1, Pages 50–54, ISSN (Online) 2335-0245, DOI: https://doi.org/10.1515/bjdm-2017-0007, March 2017