Is Dental Implantation Indicated in Patients with Oral Mucosal Diseases

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Eleni-Marina Kalogirou / Alexandra Sklavounou

Department of Oral Medicine and Pathology, Faculty of Dentistry National and Kapodistrian, University of Athens, Athens, Greece

Summary

Background/Aim: Dental implants are a reliable treatment choice for rehabilitation of healthy patients as well as subjects with several systemic conditions. Patients with oral mucosal diseases often exhibit oral mucosal fragility and dryness, erosions, blisters, ulcers or microstomia that complicate the use of removable dentures and emphasize the need for dental implants. The aim of the current study is to review the pertinent literature regarding the dental implantation prospects for patients with oral mucosal diseases. Material and Method: The English literature was searched through PubMed and Google Scholar electronic databases with key words: dental implants, oral mucosal diseases, oral lichen planus (OLP), epidermolysis bullosa (EB), Sjögren’s syndrome (SS), cicatricial pemphigoid, bullous pemphigoid, pemphigus vulgaris, scleroderma/systemic sclerosis, lupus erythematosus, leukoplakia, oral potentially malignant disorders, oral premalignant lesions, oral cancer and oral squamous cell carcinoma (SCC). Results: Literature review revealed dental implantation in patients with OLP (14 articles), EB (11 articles), pemphigus vulgaris (1 article), SS (14 articles), systemic sclerosis (11 articles), systemic lupus erythematosus (3 articles) and oral SCC development associated with leukoplakia (5 articles). No articles regarding dental implants in patients with pemphigoid or leukoplakia without SCC development were identified. Most articles were case-reports, while only a few retrospective, prospective or observational studies were identified. Conclusions: Dental implants represent an acceptable treatment option with a high success rate in patients with chronic mucocutaneous and autoimmune diseases with oral manifestations, such as OLP, SS, EB and systemic sclerosis. Patients with oral possibly malignant disorders should be closely monitored to rule out the development of periimplant malignancy. Further studies with long follow-up, clinical and radiographic dental data are required to predict with accuracy the outcome of dental implants in patients with oral mucosal diseases.

Keywords: Dental Implants; Oral Lichen Planus; Epidermolysis Bullosa; Pemphigus Vulgaris; Sjögren’s Syndrome; Systemic Sclerosis; Leukoplakia;Oral Carcinoma

References

  1. Candel-Marti ME, Ata-Ali J, Penarrocha-Oltra D, Penarrocha-Diago M, Bagan JV. Dental implants in patients with oral mucosal alterations: An update. Med Oral Patol Oral Cir Bucal, 2011;16:787-793.[Crossref]
  1. Alsaadi G, Quirynen M, Komarek A, van Steenberghe D. Impact of local and systemic factors on the incidence of late oral implant loss. Clin Oral Implants Res, 2008;19:670-676.
  2. Meijer HJ, Raghoebar GM, Batenburg RH, Vissink A. Mandibular overdentures supported by two Branemark, IMZ or ITI implants: a ten-year prospective randomized study. J Clin Periodontol, 2009;36:799-806.[Crossref]
  3. Diz P, Scully C, Sanz M. Dental implants in the medically compromised patient. J Dent, 2013;41:195-206.[Crossref]
  4. Donos N, Calciolari E. Dental implants in patients affected by systemic diseases. Br Dent J, 2014;217:425-430.
  5. Hwang D, Wang HL. Medical contraindications to implant therapy: part I: absolute contraindications. Implant Dent, 2006;15:353-360.[Crossref]
  6. Gomez-de Diego R, Mang-de la Rosa Mdel R, Romero-Perez MJ, Cutando-Soriano A, Lopez-Valverde-Centeno A. Indications and contraindications of dental implants in medically compromised patients: update. Med Oral Patol Oral Cir Bucal, 2014;19:e483-489.[Crossref]
  7. Neves J, de Araujo Nobre M, Oliveira P, Martins Dos Santos J, Malo P. Risk Factors for Implant Failure and Peri- Implant Pathology in Systemic Compromised Patients. J Prosthodont, 2016; doi:[Crossref][Crossref]
  8. Guobis Z, Pacauskiene I, Astramskaite I. General Diseases Influence on Peri-Implantitis Development: a Systematic Review. J Oral Maxillofac Res, 2016;7:1-16.
  9. Reichart PA, Schmidt-Westhausen AM, Khongkhunthian P, Strietzel FP. Dental implants in patients with oral mucosal diseases – a systematic review. J Oral Rehabil, 2016;43:388-399.[Crossref]
  10. Isidor F, Brondum K, Hansen HJ, Jensen J, Sindet-Pedersen S. Outcome of treatment with implant-retained dental prostheses in patients with Sjogren syndrome. Int J Oral Maxillofac Implants, 1999;14:736-743.
  11. Korfage A, Raghoebar GM, Arends S, Meiners PM, Visser A, Kroese GMF et al. Dental Implants in Patients with Sjogren’s Syndrome. Clin Implant Dent Relat Res. 2016;18:937-945.[Crossref]
  12. Oczakir C, Balmer S, Mericske-Stern R. Implantprosthodontic treatment for special care patients: a case series study. Int J Prosthodont, 2005;18:383-389.
  13. Chochlidakis K, Ercoli C, Elad S. Challenges in implantsupported dental treatment in patients with Sjogren’s syndrome: A case report and literature review. Quintessence Int, 2016;47:515-524.
  14. Letelier MG, Jara CC, Penarrocha-Oltra S, Gomar-Vercher S, Diago MP. Fixed Implant-Supported Full-Arch Prosthesis in Epidermolysis Bullosa With Severe Symptoms. J Oral Implantol, 2016;42:498-505.
  15. Leung WK, Chu CH, Mok MY, Yeung KW, Ng SK. Periodontal status of adults with systemic sclerosis: casecontrol study. J Periodontol, 2011;82:1140-1145.[Crossref]
  16. Aboushelib MN, Elsafi MH. Clinical Management Protocol for Dental Implants Inserted in Patients with Active Lichen Planus. J Prosthodont, 2017;26:29-33.
  17. Czerninski R, Eliezer M, Wilensky A, Soskolne A. Oral lichen planus and dental implants–a retrospective study. Clin Implant Dent Relat Res, 2013;15:234-242.[Crossref]
  18. Czerninski R, Kaplan I, Almoznino G, Maly A, Regev E. Oral squamous cell carcinoma around dental implants. Quintessence Int, 2006;37:707-711.
  19. Esposito M, Thomsen P, Ericson LE, Sennerby L, Lekholm U. Histopathologic observations on late oral implant failures. Clin Implant Dent Relat Res, 2000;2:18-32.[Crossref]
  20. Esposito SJ, Camisa C, Morgan M. Implant retained overdentures for two patients with severe lichen planus: a clinical report. J Prosthet Dent, 2003;89:6-10.[Crossref]
  21. Gallego L, Junquera L, Baladron J, Villarreal P. Oral squamous cell carcinoma associated with symphyseal dental implants: an unusual case report. J Am Dent Assoc, 2008;139:1061-1065.[Crossref]
  22. Hernandez G, Lopez-Pintor RM, Arriba L, Torres J, de Vicente JC. Implant treatment in patients with oral lichen planus: a prospective-controlled study. Clin Oral Implants Res, 2012;23:726-732.[Crossref]
  23. Lopez-Jornet P, Camacho-Alonso F, Sanchez-Siles M. Dental implants in patients with oral lichen planus: a crosssectional study. Clin Implant Dent Relat Res, 2014;16:107-115.[Crossref]
  24. Reichart PA. Oral lichen planus and dental implants. Report of 3 cases. Int J Oral Maxillofac Surg, 2006;35:237-240.
  25. Marini E, Spink MJ, Messina AM. Peri-implant primary squamous cell carcinoma: a case report with 5 years’ followup. J Oral Maxillofac Surg, 2013;71:322-326.
  26. Moergel M, Karbach J, Kunkel M, Wagner W. Oral squamous cell carcinoma in the vicinity of dental implants. Clin Oral Investig, 2014;18:277-284.[Crossref]
  27. Silva RH, Paleari AG, Brito Cde A, Rocha JF, Massucato EM, Quishida CC. A clinical report of an oral lichen planus associated to epidermoid carcinoma in contact with metallic restorations. J Contemp Dent Pract, 2014;15:651-653.
  28. Raiser V, Abu-El Naaj I, Shlomi B, Fliss DM, Kaplan I. Primary Oral Malignancy Imitating Peri-Implantitis. J Oral Maxillofac Surg, 2016;74:1383-1390.
  29. Agustin-Panadero R, Gomar-Vercher S, Penarrocha-Oltra D, Guzman-Letelier M, Penarrocha-Diago M. Fixed full-arch implant-supported prostheses in a patient with epidermolysis bullosa: a clinical case history report. Int J Prosthodont, 2015;28:33-36.[Crossref]
  30. Larrazabal-Moron C, Boronat-Lopez A, Penarrocha-Diago M, Penarrocha-Diago M. Oral rehabilitation with bone graft and simultaneous dental implants in a patient with epidermolysis bullosa: a clinical case report. J Oral Maxillofac Surg, 2009;67:1499-1502.
  31. Lee H, Al Mardini M, Ercoli C, Smith MN. Oral rehabilitation of a completely edentulous epidermolysis bullosa patient with an implant-supported prosthesis: a clinical report. J Prosthet Dent, 2007;97:65-69.[Crossref]
  32. Muller F, Bergendal B, Wahlmann U, Wagner W. Implantsupported fixed dental prostheses in an edentulous patient with dystrophic epidermolysis bullosa. Int J Prosthodont, 2010;23:42-48.
  33. Oliveira MA, Ortega KL, Martins FM, Maluf PS, Magalhaes MG. Recessive dystrophic epidermolysis bullosa–oral rehabilitation using stereolithography and immediate endosseous implants. Spec Care Dentist, 2010;30:23-26.
  34. Penarrocha M, Larrazabal C, Balaguer J, Serrano C, Silvestre J, Bagan JV. Restoration with implants in patients with recessive dystrophic epidermolysis bullosa and patient satisfaction with the implant-supported superstructure. Int J Oral Maxillofac Implants, 2007;22:651-655.
  35. Penarrocha M, Rambla J, Balaguer J, Serrano C, Silvestre J, Bagan JV. Complete fixed prostheses over implants in patients with oral epidermolysis bullosa. J Oral Maxillofac Surg, 2007;65:103-106.
  36. Penarrocha-Diago M, Serrano C, Sanchis JM, Silvestre FJ, Bagan JV. Placement of endosseous implants in patients with oral epidermolysis bullosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2000;90:587-590.[Crossref]
  37. Penarrocha-Oltra D, Aloy-Prosper A, Ata-Ali J, Penarrocha-Diago M, Penarrocha-Diago M. Implants placed simultaneously with particulated bone graft in patients diagnosed with recessive dystrophic epidermolysis bullosa. J Oral Maxillofac Surg, 2012;70:51-57.
  38. Penarrocha-Oltra D, Penarrocha-Diago M, Balaguer-Martinez J, Ata-Ali J, Penarrocha-Diago M. Full-arch fixed prosthesis supported by four implants in patients with recessive dystrophic epidermolysis bullosa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2011;112:4-10.[Crossref]
  39. Altin N, Ergun S, Katz J, Sancakli E, Koray M, Tanyeri H. Implant-supported oral rehabilitation of a patient with pemphigus vulgaris: a clinical report. J Prosthodont, 2013;22:581-586.
  40. Binon PP. Thirteen-year follow-up of a mandibular implantsupported fixed complete denture in a patient with Sjogren’s syndrome: a clinical report. J Prosthet Dent, 2005;94:409-413.[Crossref]
  41. Chatzistavrianou D, Shahdad S. Implant Treatment in Patients with Sjogren’s Syndrome: A Review of the Literature and Two Clinical Case Reports. Eur J Prosthodont Restor Dent, 2016;24:40-46.
  42. de Mendonca Invernici M, Finger Stadler A, Vale Nicolau G, Naval Machado MA, Soares de Lima AA, Compagnoni Martins M. Management of Sjogren’s Syndrome Patient: A Case Report of Prosthetic Rehabilitation with 6-Year Follow-Up. Case Rep Dent, 2014;2014:1-5.
  43. Ergun S, Katz J, Cifter ED, Koray M, Esen BA, Tanyeri H. Implant-supported oral rehabilitation of a patient with systemic lupus erythematosus: case report and review of the literature. Quintessence Int, 2010;41:863-867.
  44. Payne AG, Lownie JF, Van Der Linden WJ. Implantsupported prostheses in patients with Sjogren’s syndrome: a clinical report on three patients. Int J Oral Maxillofac Implants, 1997;12:679-685.
  45. Spinato S, Soardi CM, Zane AM. A mandibular implantsupported fixed complete dental prosthesis in a patient with Sjogren syndrome: case report. Implant Dent, 2010;19:178-183.[Crossref]
  46. Albrecht K, Callhoff J, Westhoff G, Dietrich T, Dorner T, Zink A. The Prevalence of Dental Implants and Related Factors in Patients with Sjogren Syndrome: Results from a Cohort Study. J Rheumatol, 2016;43:1380-1385.[Crossref]
  47. Krennmair G, Seemann R, Piehslinger E. Dental implants in patients with rheumatoid arthritis: clinical outcome and periimplant findings. J Clin Periodontol, 2010;37:928-936.[Crossref]
  48. Weinlander M, Krennmair G, Piehslinger E. Implant prosthodontic rehabilitation of patients with rheumatic disorders: a case series report. Int J Prosthodont, 2010;23:22-28.
  49. Baptist BA. Fixed Implant Supported Rehabilitation of Partially Edentulous Posterior Maxilla in a Patient With Systemic Scleroderma: A Case Report. Implant Dent, 2016;25:155-159.[Crossref]
  50. Haas SE. Implant-supported, long-span fixed partial denture for a scleroderma patient: a clinical report. J Prosthet Dent, 2002;87:136-139.[Crossref]
  51. Jensen J, Sindet-Pedersen S. Osseointegrated implants for prosthetic reconstruction in a patient with scleroderma: report of a case. J Oral Maxillofac Surg, 1990;48:739-741.
  52. Langer Y, Cardash HS, Tal H. Use of dental implants in the treatment of patients with scleroderma: a clinical report. J Prosthet Dent, 1992;68:873-875.[Crossref]
  53. Nam J, Janakievski J, Raigrodski AJ. Complete transition from failing restorations to implant-supported fixed prostheses in a patient with scleroderma. Compend Contin Educ Dent, 2012;33:746-756.
  54. Patel K, Welfare R, Coonar HS. The provision of dental implants and a fixed prosthesis in the treatment of a patient with scleroderma: a clinical report. J Prosthet Dent, 1998;79:611-612.[Crossref]
  55. Raviv E, Harel-Raviv M, Shatz P, Gornitsky M. Implantsupported overdenture rehabilitation and progressive systemic sclerosis. Int J Prosthodont, 1996;9:440-444.
  56. Zigdon H, Gutmacher Z, Teich S, Levin L. Full-mouth rehabilitation using dental implants in a patient with scleroderma. Quintessence Int, 2011;42:781-785.
  57. Block MS, Scheufler E. Squamous cell carcinoma appearing as peri-implant bone loss: a case report. J Oral Maxillofac Surg, 2001;59:1349-1352.
  58. Gulati A, Puthussery FJ, Downie IP, Flood TR. Squamous cell carcinoma presenting as peri-implantitis: a case report. Ann R Coll Surg Engl, 2009;91:W8-10.[Crossref]
  59. Kaplan I, Zeevi I, Tal H, Rosenfeld E, Chaushu G. Clinicopathologic evaluation of malignancy adjacent to dental implants. Oral Surg Oral Med Oral Pathol Oral Radiol, 2017;123:103-112.[Crossref]
  60. Shaw R, Sutton D, Brown J, Cawood J. Further malignancy in field change adjacent to osseointegrated implants. Int J Oral Maxillofac Surg, 2004;33:353-355.
  61. Binon PP, Fowler CN. Implant-supported fixed prosthesis treatment of a patient with Sjogren’s syndrome: a clinical report. Int J Oral Maxillofac Implants, 1993;8:54-58.
  62. Pons-Fuster A, Jornet PL. Dental implants in patients with oral lichen planus: a narrative review. Quintessence Int, 2014;45:599-603.
  63. Lekholm U. The surgical site. In: Lindhe J, editor. Clinical Periodontology and Implant Dentistry. 3rd ed. Copenhagen: Munksgaard; 1997.
  64. Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005;100:40-51.[Crossref]
  65. Taubman MA, Kawai T. Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit Rev Oral Biol Med, 2001;12:125-135.[Crossref]
  66. Alantar A, Cabane J, Hachulla E, Princ G, Ginisty D, Hassin M al. Recommendations for the care of oral involvement in patients with systemic sclerosis. Arthritis Care Res (Hoboken), 2011;63:1126-1133.
  67. Salgado-Peralvo AO, Arriba-Fuente L, Mateos-Moreno MV, Salgado-Garcia A. Is there an association between dental implants and squamous cell carcinoma? Br Dent J, 2016;221:645-649.
  68. Jane-Salas E, Lopez-Lopez J, Rosello-Llabres X, Rodriguez-Argueta OF, Chimenos-Kustner E. Relationship between oral cancer and implants: clinical cases and systematic literature review. Med Oral Patol Oral Cir Bucal, 2012;17:23-28.[Crossref]
Citation Information: Balkan Journal of Dental Medicine, ISSN (Online) 2335-0245, DOI: https://doi.org/10.1515/bjdm-2017-0013. Export Citation

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